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Liraglutide induced a significant improvement in mechanical allodynia over time compared with the vehicle-treated group (day 14: liraglutide 20 g p = 0.0098, day 28: liraglutide 20 g p = 0.0038, dexamethasone 20 g p = 0.0002, compared to vehicle-treated group)

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Systemic glutathione depletion, combined with elevated ROS, damages the endothelial lining of the blood vessels

Thus, this case of acromegaly supports our hypothesis that GLP-1 analogs are more effective than DPP-4 inhibitors for pasireotide-induced hyperglycemia

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