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Conversely, a retrospective analysis reported fewer adverse reactions, improved QoL, and longer survival with NAC 600 mg TID + pirfenidone versus pirfenidone + budesonide (143)

The compound's copper coordination is stable in the dry state

doi:10.1007/s00345-020-03140-z

In parallel, excessive Cu + generated in GSH-rich reductive environments can bind lipoylated mitochondrial TCA-cycle proteins such as DLAT, inducing aberrant protein aggregation and triggering cuproptosis across multiple cancer types 187,189,192-194

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