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While overall decline rates were similar between groups, post-hoc subgroup analysis indicated slower cognitive decline in early-onset patients (aged 65 or younger) compared to placebo, as measured by the Alzheimer's Disease Assessment Scale cognitive subscale and Clinical Dementia Rating Scale [5][18]

It is important to note that most available data reflect relatively short to medium-term exposure (typically under five years)

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7.3 Regulatory and ethical considerations for nanomedicine in oncology The ethical principles in nanomedicine, including respect for autonomy, beneficence, no maleficence, and justice, are compromised