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While there is research showing that GH treatment can result in the reduction of fine lines and wrinkles by promoting collagen growth and repair of skin tissue, a review by Bartke A et al into growth hormone and aging concluded that elevation of GH levels into the supranormal (pathological) range is associated with increased disease risks and reduced life expectancy likely representing an acceleration of aging [17]

Owing to the limitations and off-target side effects of antidiabetic drugs, exercise-induced control of hyperglycemia and increased insulin sensitivity is a preferred strategy to manage diabesity associated complications

The rationale for combining these medications lies in their complementary effects