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[3] The photograph is a doctored image of Hadfield holding a plastic zipper storage bag containing Easter eggs, [4] which Hadfield tweeted in 2013

Grading of recommendations Recommendations are graded according to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system.21 Whether a recommendation is strong or conditional will depend on considerations such as certainty in estimated effects of an intervention, including magnitude, as well as estimates of how patients value and prioritize outcomes, variability of these estimates, and wise use of resources

You might have heard your friend say it on a night out, maybe from a stranger looking to bum a smoke, or maybe youve even said it yourself

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