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In in vitro or animal models, Tau can suppress LPS/IFN--induced M1-like polarization and promote the upregulation of M2 phenotypic markers through regulatory axes associated with the methylation cycle and mitophagy (72)

July 9, 2025 [Available from: Accessed 12 Sep 2025

Furthermore, a decline in glutathione levels can trigger apoptosis signaling, and supplementation with GSH can inhibit this process, exerting a cytoprotective effect

II: comparison with major depressive disorder

Continuous MT-1 administration beyond 3 weeks causes receptor desensitization, where melanocytes downregulate MC1R surface expression in response to sustained agonist binding