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A reduction in the expression levels of the AGE receptor facilitated this effect

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Additionally, Sermorelin's effects decline when pituitary capacity is exhausted or inhibitory signals (somatostatin) are active, providing intrinsic safety compared to pharmacological GH administration

First, the chemical identification was performed once, with the methodology of the 1970s, and was not subsequently re-verified by modern peptide sequencing a point Kovalzon and Strekalova later flagged as a source of doubt about whether the isolated nonapeptide was a single defined entity or a mischaracterized fraction of a larger precursor (Kovalzon & Strekalova, 2006)