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Metformin lowers blood glucose by several different mechanisms (Viollet 2012

Injectable thiamine delivers rapid, reliable improvement in B1-deficient patientsespecially those unable to absorb oral B vitamins due to GI disease, surgery, or severe malnutrition

doi: 10.1038/nm.2313

10.1002/adbi.202200204 95 JiangQ.YinJ.ChenJ.MaX.WuM.LiuG.et al (2020)

Below are symptoms commonly attributed to b12 deficiency: Anemia Fatigue Weakness Constipation Loss of Appetite Weight loss Numbness or Tingling Depression Confusion Memory Impairment Burning Tongue/Mouth Dosages A 2015 paper published by the EFSA Panel on Dietetic Products considered 8 separate studies on Vitamin B12 ranging in dosages of 1.5-3.0 mcg/day