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In the past decade Hcy has become widely accepted as a novel risk marker associated with atherosclerotic cardiovascular disease (CVD) in the coronary, cerebral, and peripheral vascular beds

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However, the broad spectrum of symptoms belonging to either musculoskeletal or cardiorespiratory symptom clusters was similar in both wild-type and VOC infections, though more studies with higher number of observations/patients are needed to confirm the effects (183)