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Results Metabolite profiling in the motor cortex with TDP-43 pathology reveals energy deficiency and oxidative stress We previously identified major mitochondrial problems, especially within the corticospinal motor neurons (CSMN) of prpTDP-43 A315T mice 16 (Fig

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Gallbladder problems right upper abdominal pain, particularly after eating fatty foods Severe allergic reactions rash, swelling of face or throat, difficulty breathing Diabetic retinopathy complications sudden vision changes (in patients with pre-existing retinopathy) Acute kidney injury particularly in the context of severe dehydration The MHRA advises that patients should be counselled about these risks before starting treatment