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( G86R mice found aberrations of energy metabolism such as reduction of adiposity, increased energy expenditure and lipolysis, and examined the effects of a high fat diet that consisted of regular chow supplemented with 21% (wt/wt) butter fat and 0.15% (wt/wt) cholesterol

Structure-function analyses of these lipids inform rational design strategies that maximize endosomal escape efficiency while minimizing cytotoxicity [537]

The safety of incretin-based therapies The widespread extrapancreatic expression of GLP-1 and GIPR raises questions surrounding the long-term consequences of incretin-based therapies for type 2 diabetes and obesity

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