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Am J Phys 276:R929R934 Wen Y, Yang C, Menez SP, Rosenberg AZ, Parikh CR (2020) A systematic review of clinical characteristics and histologic descriptions of acute tubular injury
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In the mechanism of DKD, in addition to Kelch-1ike ECH-associated protein l (Keap1)/Nrf2/antioxidant response element (ARE) signaling, Nrf2 can inhibit inflammation to relieve kidney damage by suppressing NF-B, Sirtuin1 (SIRT1) and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)[104, 126]
