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medRxiv 2026, IQVIA PharMetrics cohort (n=20,504 non-diabetic weight-loss users), incident allodynia 35 vs 15 per 1,000 person-years against bupropion-naltrexone, adjusted HR 2.15 (95% CI 1.572.96)

Proper usage maximizes penetration, stability, and biological activity while minimizing waste and potential irritation

The honest summary: strong mechanistic and animal evidence, essentially no completed human efficacy trials

At 2.5 mg, injecting at 60 hours instead of 72 might produce mild additional nausea