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Sitagliptin administered to pregnant female rats and rabbits from gestation day 6 to 20 (organogenesis) was not teratogenic at oral doses up to 250 mg/kg (rats) and 125 mg/kg (rabbits), or approximately 30- and 20-times human exposure at the maximum recommended human dose (MRHD) of 100 mg/day based on AUC comparisons

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Moreover, many studies are short-term, which limits the insights into long-term effects of TC bioactives on gene regulation and metabolic syndrome

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A standard working concentration is 1mg/mL (0.1%): add 10mL to a 10mg vial