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This reduction in glutamine subsequently lowers GSH levels and induces endoplasmic reticulum stress, ultimately leading to the upregulation of PD-L1 expression [172]

Each method has its pros and cons

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While further research is needed to fully elucidate the mechanisms and long-term effects, this study provides strong evidence for the potential of intermittent fasting as an adjunct therapy in the management of rheumatoid arthritis, particularly in postmenopausal women who are overweight and obese

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