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Nemkov, T., Hansen, K

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Surgery, 136 (3), 557566

The effects include correcting iron imbalances associated with hypoxia, enhancing fatty acid -oxidation, and strengthening the antioxidant defense system by activating the AMP-activated protein kinase (AMPK)-nuclear factor erythroid 2related factor 2 ( NRF2 )-glutathione peroxidase 4 ( GPX4 ) axis

5 In addition, high-intensity exercise also results in an increased production of lactic acid, which can further contribute to oxidative stress by causing a decrease in pH levels in the muscle tissues