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148 Two studies investigated the association of tobacco dependence with later comorbid depression and anxiety, of which one (50%) found evidence to support this association, 149 while one (50%) found no evidence of an association

A NOS die-cut display from 1975 is a primary-source artifact from the moment when retail advertising became the tobacco industry's primary visual medium

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Inhaled nicotine rapidly reaches the brain, binding to specific receptors and triggering the release of dopaminea neurotransmitter linked to pleasure and reward