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Volkow has documented how the brain's dopamine system makes us take notice and "pay attention" to critical survival events such as food, water and reproduction, how it generates extremely durable memories, its effects upon motivation and drive, and how certain drugs like nicotine are able to take the system hostage

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The presence of major depression and an anxiety disorder were both associated with nicotine dependence

162(2): 129-37 [47] Hahn B, Stolerman IP

O., Carroll, W