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At this stage, mitochondria-directed interventions [such as mitochondria-targeted coenzyme Q10 (MitoQ) and SkQ1] can still attenuate oxidative injury but may require combination strategies (iron chelation, GPX4 preservation and mitophagy rebalancing) to achieve structural benefits (35)

Multiomic methods for subtyping are commonly carried out on brain tissue samples (Higginbotham et al., 2023

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Its well-characterized structure and solution format enable precise experimental control, reproducible dosing, and minimized variability , making it an ideal tool for mechanistic studies that require high specificity and analytical reliability