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Glycyrrhizin alleviates liver injury by precisely inhibiting the overactivation of this pathway in normal hepatocytes, which reverses cell cycle blockade and restores normal hepatocyte proliferation and function through downregulating p53/p21 and upregulating Cyclin D1, all without compromising the antitumor efficacy of gefitinib via the same pathway in cancer cells (Li et al., 2025)
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A 2025 randomized, double-blind, placebo-controlled trial published in Clinical Nutrition found that 15 mg/day of hydroxytyrosol improved antioxidant and anti-inflammatory status in overweight individuals with prediabetes over 16 weeks, while preserving insulin sensitivity (Moratilla-Rivera et al., 2025)
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Katz BJ, Lee MS, Lincoff NS, Abel AS, Chowdhary S, Ellis BD, et al
