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Investigating surrogate cerebrospinal fluid matrix compositions for use in quantitative lc-ms analysis of therapeutic antibodies in the cerebrospinal fluid

While low doses of PPR have been associated with neuroprotective effects, such as enhanced cognitive function and prevention of oxidative stress in the brain, high doses have been shown to impair cognitive performance and dampen long-term potentiation (69)

Their structural resemblance to biological membranescomprising phospholipids and cholesterol, confers enhanced biocompatibility and facilitates efficient transfollicular drug delivery [213, 214]