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Cotinine, a primary metabolite, was present at levels around 130 ng/ml whereas NNK ranged from 1.37 ng/ml to 600 ng/ml (0.7M and 6.6nM - 3M respectively)(84)

Good if you like Latakia, not if you don't

Marcuard et al., 1994

Have we not learned our lesson with the history of the big tobacco companies? Many Minnesota state legislators agree with Stium, and while some are in favor of a statewide ban on flavored tobacco products, others on both sides of the aisle have pointed out that prohibition only boosts sales in other markets rather than stemming the tide of addiction

Physiological measures (blood pressure and heart rate) were also included as non-subjective assessments, as indicated in the FDAs guidance on PMTAs 25,44