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Imaging studies have shown, for example, that a potentiated synapse can exhibit spine growth, whereas non-stimulated neighboring synapses might shrink [11] These structural modifications help lock in the functional changes, making the potentiation more durable
Furthermore, astrocytes regulate synaptic function by modulating synaptic transmission and plasticity, buffering extracellular K + , taking up neurotransmitters, and releasing gliotransmitters
The key point is that, the antinociceptive effect of nicorandil in CCI model was abrogated by methylene blue
EBioMedicine 59, 102883
Wood TR, Stubbs BJ, Juul SE
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