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Graphical Abstract 1 Introduction Stroke is a neurological disease with high disability and mortality rates, and has risen to become the second leading cause of death worldwide ( 2+ ) and an increased level of reactive oxygen species (ROS), leading to myocardial injury and cardiomyocyte apoptosis ( 2 Activation of the SNS after AIS Some specific regions of the forebrain cortex, limbic lobe, and brainstem are collectively involved in central sympathetic nervous (CSN) regulation