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Second, cotinine pretreatment diminished several effects mediated by the activation of nAChRs, including nicotine-induced increase of intracellular Ca 2+ concentrations and norepinephrine release in cultured bovine chromaffin cells (Vainio et al., 1998a, 2000), nicotine-induced dopamine release from striatal minces (Oliver et al., 2007) and nucleus accumbens (Sziraki et al., 1999), nicotine-stimulation of mouse sympathetic superior cervical ganglion neurons (Schroff et al., 2000), acetylcholine-stimulated catecholamine release from adrenal gland (Koh et al., 2003), and ganglionic stimulant-mediated increase of arterial blood ( 2 (2) 3 stoichiometry on plasma membrane of cultured undifferentiated mouse neuroblastoma 2a cells (Fox et al., 2015), consistent with desensitization-induced upregulation of nAChRs (Henderson and Lester, 2015)
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