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Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

[20] However, as an editorial opinion, we offer that the above preclinical research is pretty good support for a berberine-driven effect - especially since we're already quite familiar with berberine's other incredible effects in humans

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233 Sodium-glucose cotransporter-2 (SGLT2) inhibitors are commonly used for type 2 diabetes treatment, and in recent years, SGLT2 inhibitors canagliflozin has been shown to suppress IL-6 and IL-1 levels and MPO enzyme activity in the colon of UC rats by downregulating the expression of NF-B p65, thereby reducing colonic inflammatory cell infiltration and oxidative stress