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Reference Dickerson, Schroeder, Katsafanas, Khushalani, Origoni and Savage1,Reference Jackson, Diaz, Lopez and Leon2 A meta-analysis including worldwide studies showed that smoking rates are much higher in people with bipolar disorder than in the general population (OR = 3.5, 95% CI 3.393.54)

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Between these layers are 3 potential spaces called the epidural, subdural, and subarachnoid spaces