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In addition, exogenous antioxidants often suffer from low bioavailability and off-target distribution, diminishing their efficacy in joint tissues with dense extracellular matrices and limited vascularization (198)

Current Advances in Therapy (1) Modifying the Patients Genotype Modifying the patients genotype via hemopoietic stem cell transplantation (HSCT) was first reported to be performed over 30 years ago in an 8-year-old child who had SCD (HbSS) with frequent VOCs

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The Diagnosis and Treatment of Peripheral Lymphedema: 2020 Consensus Document