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The estimates of cumulative risk obtained in the present study reinforce the conclusion that, for people who have been smoking for many years, giving up smoking in middle age means avoiding most of the subsequent risk of developing lung cancer or of dying from a tobacco-related disease

The finding that e-cigarette provision led to significant reductions in smoking and carbon monoxide without increasing nicotine dependence has implications for reducing harm not only among the millions of smokers with SMI [serious mental illness] who struggle to quit, but also for other vulnerable smokers who cannot achieve cessation

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