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Regulation of myelin structure and conduction velocity by perinodal astrocytes

Gastrointestinal (GI) side effects, such as nausea, constipation, and bloating, are the most common, especially during dose escalation

The renoprotective effect of once-weekly GLP-1 receptor agonist dulaglutide on progression of nephropathy in Japanese patients with type 2 diabetes and moderate to severe chronic kidney disease (JDDM67)

PT-141 Synonyms / Designations: PT-141, Bremelanotide, Melanotan II analogue CAS Number: 189691-06-3 Molecular Formula: C50H68N14O10 Molecular Weight: ~1025.18 g/mol Peptide Length: 7 amino acids (cyclic peptide) Peptide Type: Synthetic melanocortin receptor agonist Purity: 99 % (HPLC, typical) Appearance: White to off-white lyophilised powder Pack Size: 10 mg (typical) Storage : Desiccated, protected from light, stored at 20 C or below Solubility: Soluble in water and buffered aqueous solutions Description & Mechanism PT-141 is a synthetic cyclic heptapeptide derived from melanocortin peptides and developed for experimental investigation of melanocortin receptormediated signalling pathways

Cell Metab 2008