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This paper updates and extends our previous meta-analysis [5] of 19 studies to add 27 additional studies, including 6 that provided adjusted odds ratios and compared the association between smoking and COVID-19 disease progression between unadjusted analyses with adjusted analyses to examine whether smoking is an independent risk factor

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Gut Microbes 16:2323234

They also warn that as relatively new products, the long-term effects of using heated tobacco have still to be properly investigated