16th century cigarettes Issued by Kinney Brothers Tobacco Company - Arouebussier, France, Century, from the Military Series (N224) issued by Kinney Tobacco Company to promote Sweet Caporal History of smoking - Wikipedia

Nicotine is highly addictive due to its ability to stimulate the release of dopamine, a neurotransmitter that creates feelings of pleasure and reward

Now the retail store being the end point of interstate commerce, and the retail store apparently in America, all retailers ignore the 18-year-old minimum age and willfully sell cigarettes to underage smokers

People who use the drug regularly have a higher risk for heart attack, stroke, and other heart disease, according to a large population-based study published in the Journal of the American Heart Association

(More on regulation in our series later this week.) But Juuls marketing may be just part of the equation

Mattingly Substance Use & Misuse 3