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However, retatrutide vs semaglutide comparisons need to account for efficacy differences

[DOI] [PMC free article] [PubMed] [Google Scholar] Terpstra M, Vaughan TJ, Ugurbil K, Lim KO, Schulz SC, Gruetter R

The article's table puts constipation at 20 to 30 percent for semaglutide and 25 to 35 percent for tirzepatide, and suggests the dual GIP and GLP-1 action may raise the risk through its effects on gut motility

Age The elderly are at increased risk because of decreased tolerance, drug interactions, reduced blood flow, poor diet, infections, and multiple hospitalizations

Community protocols describe injecting on an empty stomach food (especially carbs and fats) blunts the GH pulse