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This pathway is tightly regulated by enzymes such as ornithine aminotransferase (OAT) and pyrroline-5-carboxylate reductase (PYCR), which control proline production and, consequently, the rate of collagen deposition [13,14,15,16]

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As expected, both semaglutide and tirzepatide elicited a dose-dependent increase of clay intake, and for 9 out of the 14 dose/drug conditions, the effect was significantly greater in female than male animals (Fig

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