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The multiple regression models were tested by the likelihood ratio, the model goodness of fit was also evaluated using the Hosmer and Lemeshow test and area under the ROC (Receiver Operating Characteristic) curve

As noted by Stephens, these models only consider toxicants levels and neglect particle effects (50)

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(3) using a uniform benefit category across products within the physician office setting, regardless of whether the product is synthetic or comprised of human or animal-based material, to incorporate more consistent payment methodologies

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