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Damage to the oral-sinus cavities from GERD: Dental Erosions Mouth Ulcers Loss of taste Mouth pain Sinusitis Ear pain and inflammation Asthma and Upper Airway Problems Acid refluxed up into the back of the throat can be inhaled into the bronchial (airway) tubes and burn them, causing constriction, swelling, and large amounts of mucus production

Conversely, smoking cessation is associated with improved depression outcomes [21, 22], with a more than 40% reduction in depression risk after 30 years of smoking cessation compared to current smoking [6] and a 2% decrease in the likelihood of depression per year [19]

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Samples were visualized using a principal components analysis (PCA) (Figure S1)