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Notably, the activation of iron-regulated inflammasomes ultimately leads to oxidative stress and ferroptosis in RPECs (241)

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Frozen-then-thawed FMT units prepared from the single donor were instilled by enema and retained for 30 m in patients with HE after a 5-day course of broad spectrum antibiotics (metronidazole, ciprofloxacin, and amoxicillin) aimed to decrease host bacterial burden and make the colonic environment more receptive to colonization from the donor microbiota