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Small molecules can be chemically synthesized and potentially made more widely available, which makes the oral route attractive for large-scale investigations

It has gone through clinical trials in people, even if the results have been mixed, whereas epitalon's support rests largely on limited and preclinical work

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For example, the novel circRNA circLRFN5 binds to and degrades the PRRX2 protein through ubiquitin-mediated proteasomal degradation, downregulating PRRX2-driven GCH1 expression in glioblastomas (GBMs)

The search results from each database were then exported and imported into Rayyan, a platform specifically designed for systematic review processes, where they were screened based on the inclusion and exclusion criteria (Figure 3)