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If you are taking supplements to support your skin and joints but also consuming high amounts of refined sugar, you are essentially working against yourself

[33] The striatum's subthalamic nuclei send control signals to the globus pallidus, which initiates and modulates motion

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SCFAs and serotonin are microbe-derived chemical compounds that have the potential to regulate local vagal routes via portal circulation and send signals to the brain through the enteric nervous system (ENS) and vagal afferent routes (268, 269)