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4) Genetic and molecular pathways: dysregulation of genes involved in iron metabolism, lipid peroxidation, and antioxidant defense (e.g., SLC7A11, GPX4, Nrf2) contributes to the susceptibility of chondrocytes to ferroptosis

Sum the residue masses (monoisotopic or average) of each amino acid in the sequence, then add 18.02 Da for the water molecule lost during peptide bond formation