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Collectively, these studies underscore the implications of the wide variation in DPP1 expression and its far-reaching downstream effects, supporting future investigations of DPP1 not only as a biomarker but also as a therapeutic target to combat cancer progression

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16 Subsequent meta-analysis of 15 smaller RCTs with a total of 651 patients with DPN corroborated these results, emphasizing that the treatment with ALA (300-600 mg/day IV for 2-4 weeks) is safe and significantly improves neuropathic pain and nerve conduction velocity

These analgesic properties position DSIP as valuable research compound for developing non-opioid pain management strategies, understanding the relationship between sleep and pain processing, and investigating peptide-based approaches to chronic pain treatment