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At a recent Reddit AMA (ask me anything) Keanu truly expressed how he felt when he lost his closest friend River Phoenix, an actor and a musician from Oregon, at 23, due to a drug overdose

(15) Other theories for biological mechanism linking smoking to TED have also been proposed: smoking may have a direct irritant action on the eye, causing inflammatory changes, smoking may be a cause of stimulation of the autoimmune process in smokers and smoking may be influence the secretion of cytokine in the eye