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They can promote satiety, potentiate insulin secretion, reduce glucagon secretion, and play antiapoptotic and metabolic regulatory roles in several tissues ( However, numerous studies assessing the efficacy and safety of GLP-1 RAs in MASLD, controversy remains

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No long-term human dose-response desensitization study exists for either peptide, but the mechanism is real and users relying on twice-daily or three-times-daily injection schedules indefinitely are working against basic receptor pharmacology