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All-cause mortality, CV-related death, and fatal or nonfatal MI or stroke, hospitalization for acute coronary syndrome, and hospitalization for heart failure were also assessed as secondary endpoints

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such effects of DPP-4 inhibition on autophagy signaling were completely abolished by GLP-1R antagonist exendin 9-39 coadministration (Liu et al., 2016)

In this regard, it has been observed that similar to the remarkable therapeutic effectiveness of dual GIPR/GLP-1R agonists, the combination of GLP-1R agonism with GIPR antagonism also demonstrates significant therapeutic benefits [53,54,55]

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