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Evidently, smoking-related compounds such as nicotine penetrated the gut of smoking mice from the blood stream, thereby altering the guts bacterial composition and, consequently, the bodys metabolism.To confirm that the gut microbes were indeed major regulators of weight gain in the smoking cessation mice, the researchers collected microbiomes from smoking or smoking-cessation mice at various timepoints, and transferred these into germ-free mice that had never been exposed to cigarette smoke

Over time, this association between nicotine and alcohol can lead to a conditioned response where the consumption of alcohol triggers cravings for nicotine