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In recent years, oxidative stress has been postulated to be an important factor in the pathogenesis and development of lifestylerelated disease, such as gastroesophageal reflux.21 It is strongly agreed that ROS and reactive nitrogen species (RNS) are generated during inflammation and are considered to contribute to flogosis leading to carcinogenesis.40 In fact, chronic inflammation during GERD is an important risk factor of Barrett's oesophagus (BE) and oesophageal carcinogenesis.3 The goal of reflux treatment is not necessarily, the complete absence of symptoms, the healing of major oesophageal lesion and the prevention of complications.41 ROS and RNS can induce the formation of a variety of molecule markers of oxidative and nitrosative damage, such as the production of superoxide anion (O 2 ) and nitric oxide (NO)

Ipamorelin is a selective growth hormone secretagogue that mimics ghrelin to stimulate GH release from the pituitary

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Association between glucagon- like peptide-1 receptor agonists and biliary-related diseases in patients with type 2 diabetes: a nationwide cohort study