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Microglial complement receptor 3 can induce ferroptosis via NADPH oxidase 2 (NOX2) (60), and other NADPH oxidases, including NOX1 (61) and NOX4 (62), are also key contributors to the ferroptotic process

Resveratrol reduces oxidative stress and apoptosis in podocytes via sir2-related enzymes, Sirtuins1 (SIRT1)/Peroxisome proliferator-activated receptor Co-activator 1 (PGC-1) Axis

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Conversely, another possibility is that a lower C4B copy number might protect the stability of the host microbiome to some extent by reducing the excessive clearance of beneficial microbes mediated by C4B

The membranes were immunoblotted with following primary antibodies: Phospho-STAT1, Phospho-JAK3, Phospho-JNK, Phospho-PLC , Phospho-I B (Cell Signaling Technology, Beverly, MA, USA), STAT1, JAK3, JNK, PLC , I B (Santa Cruz Biotechnology, Dallas, TX, USA)