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doi: 10.1016/j.mayocp.2014.11.004

Ferrell's seriousness and the source material's silliness feed into one another, creating a kind of self-sustaining comedy loop that makes this film work

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35 In the brain, nicotine leads to habitual use through the nicotine receptor, and in the kidney, nicotine induces oxidative stress because nicotine is excreted by glomerular filtration and tubular secretion