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Introduction ERR (ESRRA), ERR (ESRRB), and ERR (ESRRG) are orphan nuclear receptors closely related to classical estrogen receptors but with distinct transcriptional networks

Pioglitazone Use and reduced risk of dementia in patients with diabetes mellitus with a history of ischemic stroke

Mechanisms of resistance to, and toxicities resulting from, IGF-1R-targeted drugs are well-catalogued, and there is general appreciation of the fact that a lack of biomarker-based patient stratification was a limitation of previous clinical trials

Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis

For instance, on November 8, 2023, the U.S