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Mott Childrens Hospital via a method used in many published studies

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It is made from cellulose, which is a natural polymer derived from wood pulp or cotton linters, and is then chemically modified to produce cellulose acetate

The international evidence on plain packaging highlight how plain packs increase the noticeability and impact of GHWs (12), avoid false and misleading descriptors about cigarettes (1315), and reduce positive impact including the appeal of smoking to young people (1618)

In essence, rather than lead to any safer outcomes, they just allowed the tobacco industry to capture the demand for safety, while delaying meaningful behavior change for consumers genuinely interested in mitigating risk